Root-Cause, Precision Care for Metabolic Health and Long-Term Reversal

Weight gain and diabetes are not failures of willpower—they are metabolic conditions driven by hormones, insulin resistance, inflammation, sleep disruption, genetics, medications, and lifestyle stressors. At HealthSpan Internal Medicine, Dr. Jessica Knape treats weight loss resistance and diabetes as biologic signals, not moral shortcomings.

This is physician-led, data-driven care designed to restore metabolic flexibility, protect muscle and brain health, and prevent long-term complications.

Weight Loss & Diabetes

Weight Loss Resistance: When “Doing Everything Right” Isn’t Enough

Many patients come to HealthSpan frustrated despite eating well, exercising, and “trying everything.” Weight loss resistance often reflects deeper issues such as:

  • Insulin resistance or prediabetes

  • Hormonal imbalance (thyroid, cortisol, sex hormones)

  • Chronic inflammation

  • Poor sleep or untreated sleep apnea

  • Medication effects

  • Loss of lean muscle mass

  • Genetic predisposition

Dr. Knape evaluates metabolic, hormonal, inflammatory, and nutritional markers to identify why the body is holding onto weight—and how to safely reverse that pattern

Diabetes, Prediabetes & Insulin Resistance

Type 2 diabetes and prediabetes develop gradually and are often reversible, especially when addressed early. At HealthSpan, diabetes care focuses on:

  • Improving insulin sensitivity

  • Reducing inflammatory burden

  • Preserving muscle and cognitive function

  • Preventing cardiovascular and neurologic complications

Care may include advanced metabolic testing, personalized nutrition strategies, targeted supplementation, medication optimization when needed, and ongoing coaching for sustainable change

A Precision Medicine Approach to Metabolic Health

Weight loss and diabetes care at HealthSpan may include:

  • Comprehensive metabolic and hormone testing

  • Body composition–focused strategies (fat loss without muscle loss)

  • Nutrition personalized to metabolic response and genetics

  • Sleep and stress optimization

  • Thoughtful medication review and adjustment

  • Supplement and peptide support when appropriate

This is not a one-size-fits-all program. Every plan is tailored to your physiology, goals, and stage of life.

Protecting the Brain, Heart & Longevity

Metabolic dysfunction is one of the strongest risk factors for cognitive decline, dementia, cardiovascular disease, and accelerated aging. Dr. Knape’s approach prioritizes not just blood sugar control or weight on the scale—but long-term healthspan, energy, and mental clarity.

Conditions and Risks Commonly Addressed

  • Weight Loss Resistance

  • Prediabetes

  • Type 2 Diabetes

  • Insulin Resistance

  • Metabolic Syndrome

  • Abdominal Weight Gain

  • Fatty Liver Disease

  • Diabetes-Related Fatigue or Brain Fog

A Different Kind of Weight & Diabetes Care

At HealthSpan Internal Medicine, success is measured by:

  • Improved metabolic markers

  • Sustainable fat loss

  • Preserved strength and cognition

  • Reduced medication burden when possible

  • Long-term disease prevention

If you’re struggling with weight, blood sugar, or metabolic health—and want a physician-guided, root-cause plan—early intervention matters.

Ready for a Smarter Approach?

to explore personalized care for weight loss and diabetes
at HealthSpan Internal Medicine.