Dementia Care & Cognitive Restoration (RE-CODE)
The ReCODE Protocol (Reversal of Cognitive Decline) is a comprehensive, personalized medical program created by Dr. Dale Bredesen to identify and treat the root causes of memory loss, cognitive decline, and early-stage Alzheimer’s disease. Rather than offering a single treatment, ReCODE uses advanced testing, genomics, nutrition, lifestyle interventions, and targeted therapeutics to address the multiple biological factors that contribute to brain deterioration.
Precision, prevention, and compassion for cognitive health in Boulder, Colorado
At HealthSpan Internal Medicine, Dr. Jessica Knape provides a comprehensive, root-cause approach to dementia prevention, early intervention, and cognitive restoration. With over 20 years of experience in internal and integrative medicine — and more than a decade caring for patients with Alzheimer’s and memory disorders — Dr. Knape has developed deep expertise in helping individuals and families navigate the challenges of cognitive decline with compassion, clarity, and science-based care.
A Physician Who Truly Understands
Before founding HealthSpan Internal Medicine, Dr. Knape spent over ten years working directly with patients in assisted living, memory care, and home-based medical programs. These experiences inspired her lifelong dedication to helping people protect, preserve, and even restore brain function through integrative and precision-based care.
Her approach is guided by the belief that cognitive decline is not inevitable — and that with the right strategy, brain health can be measured, supported, and strengthened at every age.
Who ReCODE Helps
(and Who Should Avoid It)
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ReCODE may help people with:
Mild cognitive impairment (MCI)
Early Alzheimer’s disease
Subjective cognitive decline
Family history of dementia
Brain fog during midlife
Metabolic problems that impair cognition (insulin resistance, low ketone availability)
Chronic inflammation or immune dysregulation
Hormone-related cognitive changes (perimenopause/menopause)
Toxin-related cognitive issues (mold, heavy metals, pollutants)
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ReCODE may not be appropriate for:
Individuals with late-stage Alzheimer’s disease
Those unable to participate in lifestyle or treatment modifications
People with uncontrolled psychiatric or neurological conditions requiring specialized care
Individuals who cannot complete recommended safety evaluations or follow-up appointments
Every case is assessed individually to ensure the safest, most effective approach.
How ReCODE Works:
Evaluation, Timeline, and Monitoring
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Your history, symptoms, exposures, nutrition, stress levels, sleep patterns, and medications are reviewed in detail. Cognitive testing is used as a baseline to monitor future improvements.
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Depending on your symptoms, this often includes:
Metabolic labs (glucose, insulin, HbA1c)
Inflammation markers (CRP, homocysteine)
Thyroid and adrenal hormones
Sex hormones (estrogen, progesterone, testosterone)
Vitamin and nutrient status (B12, D, magnesium, omega-3 index)
Toxicity screening (heavy metals, mycotoxins)
Gut-immune markers
Vascular and cardiac risk markers
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At HealthSpan Internal Medicine, we frequently use IntellxxDNA — an advanced genomics tool that identifies specific genetic patterns affecting brain inflammation, detoxification, mitochondrial function, lipid transport, methylation, and Alzheimer’s-related risk pathways (including APOE).
Genomics allow us to tailor the plan with extraordinary precision.
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Your plan may include:
Medical nutrition therapy (including ketogenic or low-glycemic patterns)
Treatment of insulin resistance
Hormone optimization when appropriate
Detoxification support if toxins are contributing
Supplements chosen to match your lab/genomic patterns
Sleep optimization
Stress regulation and nervous-system balance
Anti-inflammatory strategies
Gut microbiome restoration
Targeted treatment of chronic infections if identified
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Most people begin noticing early improvements within 6–12 weeks, with deeper changes occurring over 3–12 months.
Ongoing assessments include:
Repeat cognitive testing
Lab follow-ups
Genomics-informed adjustments
Medicaiton optimization
Symptom tracking
Lifestyle coaching and accountability
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ReCODE is generally safe when supervised by a trained clinician, but patients may experience:
Temporary fatigue as metabolic patterns shift
Digestive changes during microbiome therapy
Headaches or mood changes during detoxification
Hormone-related side effects if hormone therapy is part of the plan
These are typically manageable with dose adjustments or pacing changes.
ReCODE is not a replacement for emergency care or neurologic evaluation when needed.
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Seek urgent medical attention if you experience:
Sudden confusion or an abrupt change in mental status
New weakness, numbness, or difficulty speaking
Severe headache or vision changes
Chest pain, shortness of breath, or sudden dizziness
Rapidly worsening cognition over days to weeks
These may indicate a stroke, infection, or another medical emergency.
How We Approach ReCODE
at HealthSpan Internal Medicine
At HealthSpan Internal Medicine in Boulder, CO, we integrate the ReCODE Protocol with:
Root-cause diagnostic methods
Clinical genomics (IntellxxDNA)
Advanced labs
Precision nutrition and metabolic therapies
Early-detection strategies for Alzheimer’s risk
Personalized hormone, sleep, and stress-regulation plans
A deep commitment to patient-centered care
I (Dr. Jessica Knape) bring a decade of experience in memory care and a personal mission shaped by losing loved ones to Alzheimer’s. This work is not abstract to me — it’s personal, urgent, and deeply human.
If you’re noticing early cognitive symptoms, or if you have a family history of Alzheimer’s and want proactive prevention, the earlier we intervene, the more powerful the results can be.
Sources
National Institute on Aging: https://www.nia.nih.gov/
NIH / National Center for Biotechnology Information: https://www.ncbi.nlm.nih.gov/
Alzheimer’s Association: https://www.alz.org/
National Institute of Neurological Disorders and Stroke: https://www.ninds.nih.gov/
Apollo Health – Reversal of Cognitive Decline (100 Patients):
https://www.apollohealthco.com/reversal-of-cognitive-decline-100-patients/Bredesen DE. Reversal of Cognitive Decline: A Novel Therapeutic Program.
https://pubmed.ncbi.nlm.nih.gov/25324467/Bredesen DE et al. Reversal of Cognitive Decline: 100 Patients.
https://www.omicsonline.org/open-access/reversal-of-cognitive-decline-100-patients-2161-0460-1000450-105387.htmlToups K, Bredesen DE et al. Precision Medicine Approach to Alzheimer’s Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484109/
Medically reviewed by Dr. Jessica Knape, MD, MA
Board Certified in Internal Medicine and Integrative and Holistic Medicine
HealthSpan Internal Medicine — serving patients in Boulder, CO
About Dr. Knape | Learn more or book a consult
Disclaimer: This content is for educational purposes only and does not substitute for personalized medical care.