Men’s Health &
Andropause

Precision Care for Hormones, Metabolism, Brain Health, and Vitality

Men’s health changes quietly over time. Declining hormones, metabolic stress, inflammation, and sleep disruption often show up years before a formal diagnosis—yet they’re frequently dismissed as “normal aging.” At HealthSpan Internal Medicine, Dr. Jessica Knape takes a different approach.

Men’s health care here is rooted in internal medicine, hormone optimization, clinical genomics, and longevity science, with the goal of restoring function, resilience, and quality of life—not simply treating symptoms.

Andropause refers to the gradual decline in testosterone and other key hormones that can occur in midlife and beyond. Unlike female menopause, it’s often under-recognized and under-treated.

Common symptoms include:

  • Fatigue or low motivation

  • Decreased muscle mass or strength

  • Increased abdominal fat

  • Brain fog or difficulty concentrating

  • Low libido or erectile changes

  • Mood changes, irritability, or low mood

  • Poor sleep or reduced exercise recovery

Dr. Knape evaluates total and free testosterone, estradiol, SHBG, thyroid, adrenal hormones, metabolic markers, and inflammatory drivers to determine whether symptoms reflect hormonal imbalance—or a deeper root cause.


Andropause (Low Testosterone & Hormonal Decline)

Bioidentical Hormone Replacement Therapy (BHRT) for Men

When clinically appropriate, bioidentical hormone replacement therapy (BHRT) may be used to restore healthy hormone levels safely and thoughtfully.

BHRT at HealthSpan is:

  • Personalized (not protocol-driven)

  • Based on comprehensive labs, not symptoms alone

  • Integrated with nutrition, sleep, exercise, and metabolic optimization

  • Carefully monitored for safety and long-term outcomes

The goal is not “more testosterone,” but balanced hormones that support strength, cognition, cardiovascular health, sexual function, and longevity

Metabolic Health, Weight Resistance & Cardiovascular Risk

Men often present with weight gain, insulin resistance, fatty liver, or early cardiovascular risk before symptoms feel severe. Dr. Knape addresses these early signals using advanced metabolic testing and personalized intervention—protecting muscle, brain health, and long-term vitality.

A Different Model of Men’s Health Care

Men’s health at HealthSpan is:

  • Physician-led and data-driven

  • Root-cause focused

  • Preventive and restorative

  • Designed to extend healthspan, not just lifespan

Care may include hormone optimization, metabolic support, targeted supplementation, lifestyle medicine, and—when appropriate—advanced testing including clinical genomics.

Cognitive Health & Brain Fog in Men

Hormonal decline, sleep apnea, insulin resistance, and inflammation are major contributors to brain fog and cognitive slowing in men. Through the BrainSpan framework, Dr. Knape evaluates reversible contributors to cognitive decline and helps men protect their brain health early.

Conditions Commonly Addressed in Men

  • Andropause / Low Testosterone

  • Fatigue and Low Energy

  • Weight Resistance & Metabolic Syndrome

  • Brain Fog and Cognitive Decline

  • Sleep-Related Hormonal and Cognitive Issues

  • Reduced Exercise Recovery

  • Sexual Health Concerns

  • Cardiometabolic Risk Prevention

Men don’t need to wait until something is “wrong” to get meaningful care.
If you’re noticing changes in energy, focus, strength, or motivation, early intervention matters.

Ready to Take Control of Your Health?

to learn whether personalized men’s health care at HealthSpan is right for you.