Perimenopause — the years leading up to menopause — can bring subtle yet disruptive changes. Fluctuating estrogen, progesterone, and testosterone levels can affect nearly every system in the body.
Common symptoms include:

• Irregular or heavy periods
  
  

• Hot flashes, night sweats
  
  

• Mood changes, anxiety, or irritability

• Brain fog and memory lapses
  
  

• Weight gain, especially around the midsection
  
  

• Sleep disruption and fatigue
  
  

• Low libido or vaginal dryness
  
  

At HealthSpan, Dr. Knape addresses perimenopause using bioidentical hormone replacement therapy (BHRT), precision lab testing, and lifestyle optimization. Each plan considers your metabolism, genetics, and environmental influences to restore balance naturally. The goal isn’t just symptom relief — it’s whole-body restoration, helping you move into menopause with stability, clarity, and renewed energy.

Hormone imbalance can occur at any age and can impact energy, mood, weight, focus, and sexual health.

Dr. Knape evaluates thyroid, adrenal, and sex hormones to uncover subtle dysfunctions and tailors treatment through BHRT, nutrition, stress regulation, and metabolic optimization.

Cognitive symptoms — from mild forgetfulness to early dementia — are a growing concern. Dr. Knape applies the BrainSpan and ReCODE frameworks to detect and reverse cognitive decline through precision diagnostics, genomics (including IntellxxDNA®), and targeted therapies addressing inflammation, insulin resistance, and nutrient deficiency.

Weight that won’t budge despite “doing everything right” often reflects deeper issues: insulin resistance, thyroid imbalance, inflammation, or hormonal disruption.

Through medical weight loss programs, metabolic testing, and nutrition personalized to your DNA, Dr. Knape helps restore efficient metabolism and long-term fat loss while protecting muscle and energy.

Chronic stress, nutrient depletion, and environmental toxins can impair thyroid and adrenal function, causing fatigue, anxiety, or weight gain. Dr. Knape evaluates full thyroid panels (not just TSH) and adrenal stress markers, correcting imbalances with functional and hormone-based care for sustainable recovery.

Persistent fatigue is rarely “just in your head.” It often stems from mitochondrial dysfunction, chronic infections, immune imbalance, or toxin exposure. Dr. Knape uses precision diagnostics and functional medicine to identify these contributors and guide targeted recovery strategies.

Dr. Knape’s approach to longevity medicine focuses on extending your healthspan — the years you feel strong and vital — through advanced testing, hormone optimization, genomics, and proactive prevention of cognitive and metabolic decline.

• Andropause (Low Testosterone in Men)

• Anxiety, Mood & Sleep Disorders

• Osteopenia & Bone Health Optimization

• Cardiovascular Risk Prevention

• Autoimmune Conditions

• Gut and Digestive Health Imbalance
  Detoxification & Environmental Sensitivity

• Post-COVID or Post-Viral Fatigue

• Autoimmune conditions

• Fibromyalgia