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Chronic Fatigue & Inflammation

Identify the root causes. Restore energy. Rebuild resilience.

Persistent fatigue, brain fog, low motivation, pain, and inflammatory symptoms are often dismissed as stress, aging, or “normal life.” At HealthSpan Internal Medicine in Boulder, Colorado, Dr. Jessica Knape takes a different approach — recognizing chronic fatigue and inflammation as biological signals, not character flaws.

Using precision medicine and advanced diagnostics, we uncover the underlying drivers of fatigue so you can feel energized, clear, and capable again.

🌿 Why Fatigue Happens

Chronic fatigue is rarely caused by one thing. It often reflects a complex interplay of systems, including:

  • Metabolic dysfunction or insulin resistance

  • Mitochondrial impairment

  • Hormone imbalance (thyroid, adrenal, sex hormones)

  • Chronic infection or immune dysregulation

  • Nutrient deficiencies

  • Gut or microbiome imbalance

  • Environmental toxins or mold exposure

  • Sleep and circadian disruption

  • Emotional and cognitive stress load

When these imbalances persist, the body enters an energy-conserving, inflammatory state — leaving you exhausted, achy, foggy, and disconnected from life.

🧬 Clinical Genomics to Personalize Treatment

At HealthSpan, clinical genomics (IntellxxDNA®) is used to identify genetic variations that influence:

  • Inflammation

  • Detoxification

  • Methylation

  • Mitochondrial function

  • Immune response

  • Hormone metabolism

  • Stress sensitivity

These insights allow us to understand why your body responds the way it does — and tailor treatment to your unique physiology.

Genomics can explain why some patients experience fatigue, pain, or sensitivity despite “normal labs” — and helps us target solutions with greater accuracy.

🌱 Precision Treatment for Whole-Body Repair

Treatment is personalized and may include:

  • Nutrient repletion and mitochondrial support

  • Anti-inflammatory nutrition and lifestyle strategies

  • Gut healing and microbiome restoration

  • Hormone optimization (thyroid, adrenal, sex hormones)

  • Targeted antimicrobial or detoxification therapies

  • Sleep and stress regulation strategies

  • Cognitive and emotional resilience practices

Our goal is not to “push through,” but to help you recover physiologic capacity so energy becomes sustainable, not fragile.

🩺 Why HealthSpan Internal Medicine

Under the leadership of Dr. Jessica Knape, a dual-board-certified physician with expertise in internal, integrative, and genomic medicine, HealthSpan provides compassionate, high-skill care for patients with complex, misunderstood, or prolonged fatigue.

Many patients come to us after years of feeling unheard — finally ready to understand what’s happening in their body and how to heal.

❓ Frequently Asked Questions

➕ Can chronic fatigue be reversed?

Often, yes — when underlying drivers are identified and addressed with targeted therapy.

➕ Why don’t standard labs find anything?

Routine testing looks for disease — not dysfunction. Fatigue often reflects subclinical imbalances that require deeper evaluation.

➕ How long does recovery take?

Timelines vary, but most patients experience meaningful improvement within 3–6 months when root causes are corrected.

➕ Do you treat chronic inflammatory conditions like Long COVID or autoimmune disease?

Yes — both are addressed through precision, whole-person care.

For more questions, visit our FAQ: Chronic Fatigue & Inflammation page.

🌿 Take the First Step Toward Energized Living

You don’t have to live in survival mode.

Let’s uncover the root causes — and help your body heal.